Keep methadone hydrochloride tablets out of the reach of children. Accidental overdose by a child is a medical emergency and can result in death. If a child accidentally takes methadone hydrochloride tablets, get emergency help right away.
Regardless of the dose determination strategy employed, methadone is most safely initiated and titrated using small initial doses and gradual dose adjustments.
Pharmacodynamic interactions may occur with concomitant use of methadone and potentially arrhythmogenic agents such as class I and III antiarrhythmics, some neuroleptics and tricyclic antidepressants, and calcium channel blockers.
Methadone can Beryllium abused hinein a manner similar to other opioid agonists, legal or illicit. This should be considered when prescribing or dispensing methadone hydrochloride tablets hinein situations where the clinician is concerned about an increased risk of misuse, abuse, or diversion.
Rein the selection of an initial dose of methadone hydrochloride tablets, attention should be given to the following:
This drug can make you very drowsy. You shouldn’t drive, use machinery, or do other activities that require alertness after you’ve taken this drug.
If you take too much: You could have dangerous levels of the drug hinein your body. Symptoms of an overdose of this drug can include:
Patients should Beryllium cautioned that alcohol and other CNS depressants may produce an additive CNS depression when taken with this product and should be avoided.
Opioid antagonists should not Beryllium administered in the absence of clinically significant respiratory or cardiovascular depression. Rein an individual physically dependent on opioids, the administration of the usual dose of an opioid antagonist may precipitate an acute withdrawal syndrome.
These can Beryllium symptoms that you have taken too much (overdose of) methadone hydrochloride tablets, or the dose is too high for you. They can also Beryllium symptoms of a serious heart reaction. These symptoms can lead to serious problems or death if not treated right away.
Patients initiating treatment with methadone for opioid dependence should be reassured that the dose of methadone will “hold” for longer periods of time as treatment progresses.
The safety and effectiveness of this drug Methadontabletten 10 mg online hasn’t been established rein children. It shouldn’t be used in children younger than 18 years.
Although with single-dose administration the onset and duration of analgesic action, as well as the analgesic potency of methadone and morphine, are similar methadone's potency increases over time with repeated dosing. Furthermore, the conversion ratio between methadone and other opiates varies dramatically depending on baseline opiate (morphine equivalent) use as shown hinein the table below.
Respiratory depression is the chief hazard associated with methadone hydrochloride administration. Methadone's peak respiratory depressant effects typically occur later, and persist longer than its peak analgesic effects, particularly rein the early dosing period.